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10.1074/jbc.C300349200 91 HeatonR

The basis was the findings that DSIP modulates endogenous opioid peptidergic systems and has a significant effect on circadian rhythms and cortisol levels

Our work, in combination with that of others, suggests that it is the peptide metabolites of oxytocin that are responsible for the enhanced cognition, and that angiotensin IV prevents its effects by inhibiting IRAP (oxytocinase) and the metabolism of oxytocin