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In photoaged skin, UV radiation interacts with oxygen molecules within the body, leading to the generation and accumulation of ROS (54)

Candida albicans evades NK cell elimination via binding of agglutinin-like sequence proteins to the checkpoint receptor TIGIT

As we age, skin thickens due to loss of moisture and collagen

Deficiency can lead to megaloblastic anemia and neurologic complications, while elevated levels may signal underlying liver disease or malignancy

4.2 Folate supplementation targets methionine metabolism Folate is a methyl donor required for the synthesis of methionine, a precursor of SAMe, a substrate for methylation in epigenetic and epigenomic pathways