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Drugs, such as LOXL2 (lysyl oxidase-like 2) Inhibitors, aiming at reducing ECM crosslinking, can lead to a softer, more permeable matrix

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In this study, we engineered Geobacillus thermoleovorans through adaptive laboratory evolution (ALE) for robust growth on adipic acid (AA) and 1,4-butanediol (BDO), two relevant monomers for example derived from poly(butylene adipate- co -terephthalate) (PBAT), enabling growth rates of up to 0.10 h 1 on AA and 0.13 h 1 on BDO

But there are also treatments that can help

In a double-blind randomized trial, a 0.1% curcumin mouthwash used twice daily significantly reduced plaque index (PI), gingival index (GI), and bleeding index over 4 weeks, with efficacy statistically equivalent to 0.2% chlorhexidine and superior to placebo (Terby et al., 2021)