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[105] investigated the effects of overloaded training (OT) with athletes exercising for a duathlon before and after a four week OT and found that at rest conditions, OT induced an increased plasma GPX activity and a decreased plasma total antioxidant status, while OT resulted in higher exercise-induced variations of blood GSH/GSSG ratios, TBARS levels and decreased total antioxidant status in exercise conditions indicating that OT could compromise the antioxidant defense mechanisms