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To determine if the administered treatment presents toxic effects on normal cells, we cultured rat neural stem cells (NSCs) to simulate 3D culture conditions in normal neurospheres (Fig

65 This protection is achieved through a variety of biological processes, including interactions with transition metals, neutralization of free radicals, modification of the activity of different enzymes, and impacts on intracellular signaling pathways and gene expression

Researchers have recently observed a significant protective effect against KA-induced excitotoxicity and hippocampal superoxide production in vivo in Tau gene knockout mice [144]

Arch Toxicol 88:391401 McJunkin B, Barwick KW, Little WC, Winfield JB (1976) Fatal massive hepatic necrosis following acetaminophen overdose