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Although AI enhances the rational design of inhalable formulations, physicochemical properties must also be carefully engineered to maximize drug retention and cellular uptake

Receptor-mediated targeting may further be combined with non-specific drug delivery systems (like protein conjugates, PEGylation, nanoparticles, liposomes, and the like) to greatly improve the pharmacokinetic and biodistribution properties of the drugs, which will significantly redirect the drugs specifically to receptor-expressing cells, tissues and organs, including the ones protected by specific blood-tissue barriers like e.g., the CNS, the blood-brain barrier (BBB), the retina and the testes

From research synthesis to commercial manufacturing, with integrated analytical, regulatory, and catalog services at every phase

PMID: 17505081

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