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(2021) 4:e2122607

ISBN 978-94-6239-545-9

When determining the Alanine to Lysine ratio as an indirect measure of mitochondrial distress we found that unaffected children had an average ratio of 5.8 and those with konzo have an average ratio of 6.9, both of which are substantially higher than the expected ratio of less than 3 for healthy adolescents (Fig

Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner

The binding sites of these direct InhA inhibitors can be divided into several regions: the catalytic or active site, the hydrophobic pocket that accommodates the substrates long alkyl chains, and the solvent-exposed site that is termed the size-limited region [52, 82, 83]