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RNA - seq indicates that DHA/EPA may enhance the efficacy of bortezomib by activating ferroptosis - related signaling pathways, suggesting that ferroptosis may play a positive role in improving drug sensitivity and overcoming drug resistance in the treatment of MM ( In conclusion, ferroptosis - related genes may become important factors for MM prognosis assessment, and more relevant genes still need to be explored through experiments

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Microscopy Most high resolution fluorescence micrograph data were captured on Zeiss Axiovert Z1 microscope equipped with X-Light V2 Spinning Disk Confocal Unit (CrestOptics), 7-line LDI Laser Launch (89 North), Photometrics Prime 95B Scientific CMOS camera, using Metamorph 7.7 software

Importantly, given that mild fasting results in energy stress and a decline in the levels of growth factors, leading to increased AMPK and GSK3 activity, it can be predicted that fasting would boost SIRT7 functions in normal tissues/organs, as has been reported previously in liver 20