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Adenosine A2A receptor antagonists, such as istradefylline, can relieve off periods and enhance patients motor functions (Rascol et al., 2015)

There are several rodent studies that show very similar results in nerve density in biopsies

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Furthermore, AD may promote ferroptosis by encouraging mitochondrial dysfunction, raising lipid peroxidation, and suppressing the production of GPX4 and SLC7A11, consequently reducing the growth and spread of non-small cell lung cancer cells (Jiaqi et al