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For total proteome experiments, digested peptides were separated using the following gradient: 70 minutes from 5% to 20% buffer B (0.1% formic acid, 80% acetonitrile), 15 minutes from 20% to 30% buffer B, 5 minutes from 30% to 65%, and 5 minutes from 60% to 95%, at a constant flow rate of 300 nl/min

Mitochondrial dynamics While often not specifically defined as a quality control mechanism, it warrants consideration that dynamics are also regarded to be a mechanism utilized by mitochondria to promote repair

Pharmacogenet Genomics 17:773782 Acknowledgements We would like to thank Editage (www.editage.com) for English language editing

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