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The Pax7 transcription factor has been shown to be a key determinant of melanotroph identity, and it works by remodeling chromatin prior to Tpit expression, opening key areas of chromatin to allow Tpit and other transcription factors access to enhancers, resulting in melanotroph specification (13)

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As a general rule, black inks are easiest to fade, while bright and pastel colors will be more difficult

This is done through certain medications which can remove excess copper from the vital organs & release it into the bloodstream, which is then filtered out through urine by the kidneys