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The inclusion criteria were original research articles (including in vitro , in vivo , and clinical studies), high-quality systematic reviews, and meta-analyses published in English

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Biomaterials 150 , 125136 (2018)

References Comparison of the clinical efficacy and safety of subcutaneous versus oral administration of methotrexate in patients with active rheumatoid arthritis: Results of a six-month, multicenter, randomized, double-blind, controlled, phase IV trial The main goal of this study was to compare the efficacy and safety of subcutaneous (SC) versus oral administration of methotrexate (MTX) in patients with active rheumatoid arthritis (RA)