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But over time, the effects of heredity, unhealthy habits, and age can cause the buildup of artery-damaging plaque and calcium deposits

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(download TIFF Effects of 4-hydroxy-tamoxifen alone and with PCS-833 on the growth of AuxB1 and CHO R C5 cells- Cells were plated 24hrs prior to the addition of increasing concentrations of 4-hydroxy-tamoxifen alone and in the presence of an inhibitor of P-gp ATPase (PSC-833)

The polyunsaturated fatty acids (PUFAs) within mitochondrial and cellular membranes are particularly vulnerable to ROS-mediated peroxidation, yielding cytotoxic byproducts such as MDA and 4-hydroxynonenal (4-HNE) (62)