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It is a selective GLP-1 receptor agonist, and all of its reported metabolic effects trace back to GLP-1 receptor activation, whether in the pancreas, the hypothalamus and hindbrain, or the gut

doi: 10.1016/0092-8674(78)90308-2

A reduction in G i2 protein, but not G o and G s , expression has been described in cabergoline-resistant with respect to sensitive prolactinomas ( i13 proteins has been reported in GH-secreting tumors ( Alterations in SSTRs signal transduction might be the cause of typical octreotide-resistance observed in acromegalic patients bearing germline mutations in aryl hydrocarbon receptor interacting protein (AIP) gene ( i signaling ( Genetic analysis of AIP in 50 non-familial acromegalic patients resistant to treatment with SS analogs revealed a low, but non-negligible, prevalence of AIP germline mutations ( Fougner et al