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2.4 MC activation For IgE-mediated activation, RBL cells (8 X 10 6 cells/plate) were grown overnight in the presence of a 1:512 dilution of conditioned media derived from a DNP specific IgE secreting Hybridoma and LAD-2 cells (0.5 X 10 6 cells/ml) were grown overnight in the presence of 0.5 g/ml of human myeloma IgE

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Taking myocardial remodeling as an example, while traditional perspectives emphasize its association with hemodynamic overload or neurohormonal activation, recent studies reveal that mitochondrial dysfunction exhibits dual pathological mechanisms in CVDs

To refer to the simulations, we use the following conventions: ICON-C X and IFS_F-C X , in which X indicates the cycle and IFS_F stands for IFS-FESOM