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This dynamic is evident in therapy resistance and metastasis

MCs play a crucial role in phagocytosis and the removal of foreign bodies

Avelumab maintenance therapy for advanced or metastatic urothelial carcinoma

Hence, there is an urgent need to construct a multifunctional nanoplatform that can not only deliver a high dose of iron but also inactivate GPX4 or consume GSH to achieve efficient ferroptosis induction