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Description

When pathogen-derived or endogenous ligands are detected by injured cells, pattern recognition receptors (PRRs), which are produced by astrocytes and microglia, start the innate immune response [66]

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Warnings: Patients with early Leber's disease (hereditary optic nerve atrophy) may experience severe and rapid optic atrophy when treated with vitamin B12. Additionally, treating severe megaloblastic anemia with vitamin B12 can lead to fatal hypokalemia due to increased erythrocyte potassium requirements

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The adverse event profile was statistically indistinguishable from placebo

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Circulation 133 , 706716 (2016)

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J Invest Dermatol (1996) 107:510

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