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We also explored the expression of the Keap 1-Nrf2--antioxidant response element signaling pathway that is known to regulate several protective mechanisms, including the expression of antioxidant and anti-inflammatory events

A combination of prolonged oxidative damage and hepatocellular proliferation is postulated to be responsible for liver tumor development, with tumor development primarily a result of enhanced growth of preneoplastic foci

Additionally, long COVID research studies and medical histories tend to document only the risk factors for severe acute COVID-19, which are different from the risk factors for conditions that overlap with long COVID such as ME/CFS and dysautonomia (for example, connective tissue disorders such as EhlersDanlos syndrome, prior illnesses such as infectious mononucleosis and mast cell involvement) 33,195,196

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