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Physiological ovarian aging (NOA) is the gradual loss of ovarian reserve function in older women until they reach menopause while pathological ovarian aging is the premature ovarian failure caused by various pathogenic factors, including decreased ovarian reserve (DOR), ovarian insufficiency (POI) and poor ovarian response (POR) ( in vivo , and in vitro research

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The effect is mediated by stacking between ebselen or ebsulphur aromatic rings and increases the dimer binding energy by exclusion of water

ANOVA with Brown-Forsythe post-hoc test for multiple comparisons was performed to determine statistical significance (* P = 0.0203)