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The researchers thus hypothesized that blocking NNMT could open a novel path to treating obesity and its metabolic complications [1, 2]

Endotoxin levels should remain below 1 EU/mg for injectable use

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The discovery that NNMT expression is dramatically elevated in adipose tissue of obese humans and animal models, and that NNMT inhibition or knockdown prevents diet-induced obesity and improves metabolic health, has catalyzed intense research interest in NNMT as a therapeutic target for obesity, metabolic syndrome, and related conditions