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NMDA receptor activation: critical role in oxidant tissue injury

Medical Review July 2022 by Mitchell Grayson, MD JOIN NOW References 1

In a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinsons disease mouse model, treatment with Lf-ASX-LPs resulted in 5.0-, 3.1-, and 5.6-fold increases in dopamine levels, TH + fiber density, and TH + neurons, respectively, restoring dopaminergic neuron damage

The study found increases in IGF-1

By contrast, other techniques such as mass spectrometry-based imaging, synchrotron X-ray fluorescence and electron microscopy with elemental detectors are powerful for quantifying total zinc and mapping its distribution in fixed specimens at the nanometer resolution