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Finally, Kuethe et al

10.1016/j.freeradbiomed.2004.04.034 Free Radic

However, due to the complexity and ethical constraints of clinical trials, it is difficult for the latter to conduct large-scale and long-term follow-up, and in contrast, most clinical RCTs aim at the validation of symptomatic drugs such as calcium, vitamin D, and BPs, while the microecological modifiers that target the gutbone axis are seldom screened

Science 292(5517):727730

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