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Early evidence highlighted the liver as the major organ involved in the effect of metformin on reducing blood levels of glucose

10.1371/journal.pone.0162590 41 LueticK.SucicM.VlainicJ.HalleZ

Th17 cytokines play a protective role in Mtb infection but are also involved in pathology due to excessive immune response (250)

Within this framework, ROS function as dual regulators: excessive accumulation drives cellular damage, whereas tightly controlled ROS flux acts as a secondary messenger integrating Ca 2 signaling and amplifying both ABA-dependent and ABA-independent responses