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A total of nine selenoproteins have been identified in human fetal osteoblasts where they play a role in bone metabolism (Reference Zeng, Cao and Combs15)

The antibody-drug conjugate according to claim 1, wherein D is a moiety of formula (V)WhereinX is C or N, preferably N;R11 is selected from the group consisting of H, and C 1 -C 12 alkyl,L' is a bond or a linker, preferably selected from C 1 -C 12 alkylene, C 1 -C 12 heteroalkylene, C 3 -C 6 cycloalkylene, heterocyclylene having 5 to 10 ring atoms, arylene having 6 to 10 ring atoms, heteroarylene having 5 to 10 ring atoms, and any combination thereof, and Ring B is a heterocycloalkyl having 3 to 10 ring atoms, or a heteroaryl having 5 to 10 ring atoms, said heterocycloalkyl and heteroaryl being optionally substituted, preferably by one or more substituent selected from -OH, =O, C 1 -C 12 alkyl, C 1 -C 12 heteroalkyl, C 3 -C 6 cycloalkyl, heterocyclyl having 5 to 10 ring atoms, aryl having 6 to 10 ring atoms, heteroaryl having 5 to 10 ring atoms, -(C 1 -C 12 alkyl)-(C 3 -C 8 cycloalkyl), -(C 1 -C 12 alkyl)-(heterocycloalkyl having 3 to 10 ring atoms), -(C 1 -C 12 alkyl)-(heteroaryl having 5 to 10 ring atoms), -(C 1 -C 12 alkyl)-(aryl having 6 to 10 ring atoms), and -NR'R"

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Ocrelizumab ist derzeit das einzige Medikament, das fr die Therapie der primr chronisch progredienten MS zugelassen ist