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Therefore, understanding the regulation of autocrine/paracrine synthesis of IGF-1 is necessary to interpret changes in serum IGF-1 concentrations

Emerging human evidence of MNP-associated cardiovascular risk Although most of the existing data on MNP-induced cardiotoxicity is derived from in vivo and in vitro experimental models, recent human studies have begun to reveal compelling links between MNP presence and cardiovascular disease outcomes

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Conclusion: GC alleviates AS via a novel LAMP-2A-dependent mechanism that enhances protein clearance and suppresses NLRP3 inflammation, providing a targeted alternative to broad immunosuppression

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