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However, if the inflammatory response remains uncontrolled in the early stages of tendon healing, it can lead to an excess of pro-inflammatory cytokines and over-deposition of ECM due to prolonged inflammatory signaling, resulting in excessive fibrotic repair (85)

For purposes of this invention, the heteroatoms such as nitrogen may have hydrogen substituents and/or any permissible substituents of organic compounds described herein which satisfy the valences of the heteroatoms

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15,19 Ivacaftor increases chloride transport via potentiation of CFTR channel gating of the CFTR protein on epithelial cell surfaces

superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), glutathione peroxidase (GPx), vitamin C, and E, and a significant improvement in PFTs versus control group and baseline levels