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Description

TamtajiORMilajerdiAReinerAsemiZDadgostarEHeidari-SoureshjaniRet al

In animal models, mice with decreased NNMT levels exhibited heightened energy expenditures compared to control mice of similar weights (Kraus et al., 2014)

The follow-up pivotal trial (METAOD006 / OPTIONS) enrolled a larger cohort and failed to replicate statistically significant weight loss, which led Metabolic Pharmaceuticals to halt the formal drug development program in 2007