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& Gastaminza, P

This metabolic shift changes mitochondrial ratios of acetyl-CoA and nicotinamide adenine dinucleotide (NAD+)/nicotinamide adenine dinucleotide + hydrogen (NADH), positively impacting the redox state of cells [6, 9], and limiting seizure activity [10]

10.1016/j.cmet.2013.06.015 Cell Metab

The name and homology details of AIFM2 indicate how it was identified by its function to induce apoptosis by releasing cytochrome c and caspase 9 (Miriyala et al., 2016)

Thus, serum IGF-1 levels correlates with the circulating leptin concentration in patients undergoing peritoneal dialysis and hemodialysis, but not in patients treated with conservative therapy.86 Interestingly, administration of recombinant IGF-1 decreases serum leptin concentration in patients undergoing hemodialysis