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TRAP-1 supports tumor growth by promoting glycolysis, inhibiting succinate dehydrogenase, and activating cytochrome-c oxidase, 234,235,236 although reduced TRAP-1 expression at later stages has been linked to enhanced motility and invasion, suggesting context-dependent roles

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As for most other enzymes of the pathway, SIR may be persulfidated, but neither the cysteine affected nor the effect on activity have been explored (Figure 2 and Supplementary Table 2)