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J.RoseM.HertzL.DhaliwalA.Moran-MirabalJ

3C, Supplementary Data 2)

Excessive ROS are key triggers of mitochondrial outer membrane permeabilization (MOMP) by activating and oligomerizing apoptogenic factors Bcl-2-associated X protein (BAX) and Bcl-2 homologous antagonist/killer (BAK) [7, 33, 34, 41], leading to the release of cytochrome c and the activation of caspases-9, 3 and 7 [42,43,44]