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TOP THE GUIDELINES AND PROTOCOLS ADVISORY COMMITTEE The principles of the Guidelines and Protocols Advisory Committee are to: encourage appropriate responses to common medical situations recommend actions that are sufficient and efficient, neither excessive nor deficient permit exceptions when justified by clinical circumstances Contact Information: Guidelines and Protocols Advisory Committee PO Box 9642 STN PROV GOVT Victoria BC V8W 9P1 Email: [email protected] Website: www.BCGuidelines.ca Disclaimer The Clinical Practice Guidelines (the Guidelines) have been developed by the Guidelines and Protocols Advisory Committee on behalf of the Medical Services Commission

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The intracellular ROS levels are meticulously governed by an intricate interplay of mechanisms governing both ROS generation and elimination (Fig

In case of a darker complexion or an uneven skin, there is also an elevated production of Eumelanin (a pigment responsible for imparting the dark brown color)