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Given that a variety of cells in the lymph nodes possess the ability to express PD-L1, including LECs (94, 95, 98), FRCs (215), dendritic cells (203), macrophages, B cells, T cells, and NK cells (204, 208, 209), understanding the impact of PD-1/PD-L1 immune checkpoint blockade on these cells and their interactions with T cells in the TDLNs might provide novel solutions to further enhance the efficacy of immunotherapy

Support Mood Balance: Nutrients like Choline can improve mood and reduce stress eating

As a new system biology method, metabolomics is increasingly used to evaluate metabolic disorders in human diseases, which has a good prospect of finding new disease biomarkers, clinical diagnosis, and efficacy prediction (11, 12)

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Abstract Background Tendon stem/progenitor cells (TSPC) exhibit a low proliferative response to heal tendon injury, leading to limited regeneration outcomes