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However, worth mentioning that genes related to cumulus expansion such as HAS2, PTX3, GREM1, and VCAN were of great value to be used as potential oocyte markers in PCOS as it highly correlates with the regulation of oocyte signals and has important functions in cumulus expansion and metabolism ( Publishers Note All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers