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Diabetes 49 , 12191223 (2000)

[DOI] [PubMed] [Google Scholar] 49.Chen J, Tang XQ, Zhi JL, Cui Y, Yu HM, Tang EH, Sun SN, Feng JQ, and Chen PX

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In various tumor types, p53 mutations not only result in the loss of its tumor suppressor function but may also confer new oncogenic functions to the mutated p53, a phenomenon termed gain-of-function (GOF) ( The p53 protein plays a crucial role in cell cycle regulation and apoptosis