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Shikonin inhibits tumor growth in mice by suppressing pyruvate kinase M2-mediated aerobic glycolysis

On the other hand, mitochondrial fragmentation also leads to excessive accumulation of reactive oxygen species (ROS), further damaging T-cell DNA and proteins, exacerbating cellular functional decline (146)

We specifically explore how genomic testing may be used in three primary radiotherapy applications for BM: patient stratification, early radiation treatment response monitoring, and selection of systemic therapies for use in combination with radiotherapy