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J Clin Med 2023;12 (10)

There is hope that this may lead to advanced therapies for osteoarthritis and may even eliminate the need for surgery in certain settings [7]

It also exists in a soluble form (sKlotho) which is generated by cleavage of the extracellular domain of -Klotho, which circulates in the blood and also exerts systemic effects, including cardioprotective properties, which are still poorly understood [80, 82]