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10.1007/s11010-014-2187-z 73 RichardsonS

LRRK2 is located mainly in the cytoplasm, although approximately 10% of LRRK2 is located to the mitochondria and regulates mitochondrial function ( LRRK2 mutations in DA neurons were associated with an increased susceptibility to oxidative stress ( VPS35 Vacuolar protein sorting 35 (VPS35), composed of 796 amino acids, is a core component of the retromer complex and participates in endosomal-lysosomal transport

These dicarboxylic acids can enter the tricarboxylic acid cycle to release substantial amounts of energy or participate in further metabolic reactions with other bodily substances (Liao, et al., 2024)