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Schmidt C

Konarev, P

Its high prevalence poses significant social burdens, severely affecting physical and mental health, with rising trends in drug abuse 1,2,3,4

In the immune response, tumor cells exhibit high levels of CD47 expression, which impedes phagocytosis by macrophages through its binding to SIRP on the macrophage surface, thereby facilitating immune evasion

Moreover, an antibodydrug conjugate combining the anti-CD26 monoclonal antibody YS110 with triptolide (Y-TR1) selectively targets CD26-positive cancer cells (malignant mesothelioma and leukemia), effectively inhibiting RNA polymerase II activity [1027]