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Pro-inflammatory cytokines like TNF-alpha, IL-1beta, and IL-6 damage surviving nerve fibers, interfere with Schwann cell repair functions, and create a hostile environment for axonal regrowth

Because bone and joint damage occur later in the course of the disease, X-rays may not be very useful in detecting RA in the early stages, although soft tissue swelling around a joint can be seen on a regular X-ray

They are not approved by the FDA or EMA as drugs for specific indications related to mitochondrial energy or aging