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Elesclomol is widely recognized to induce copper overdose and cell death (139), by acting as a copper ion carrier with a hydrophilic pore in its centre, to which Cu2+ ions can bind easily, facilitating copper entry into cells, thus increasing the intracellular copper concentration (140), and this, in-turn increases ROS levels, triggering oxidative stress (141) and ultimately cell death

methodology and software: S.B.A

Most common salts of Epitalon available commercially are in combination with acetic or trifluoroacetic (TFA) counterions

Finally, in order to enhance the efficacy of therapeutic agents, it is crucially important to develop drug delivery systems that enable supersulfide donors to target affected areas

To further characterize compound engagement of TGR in ex vivo worms using an orthogonal assay, inhibition of TGR activity in newly transformed schistosomula (NTS, skin-stage worms) was assessed using a TrxR-selective fluorescent probe 43,44 , TRFS-Green