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Thus, in our view, while the present concept holds huge and undisputable theoretical and practical impact, the injury course in the stomach itself so far implements only unprepared stomach when direct delivery through a tube inserted into the stomach skips a normal defensive system in the upper part of the gastrointestinal tract (1-3)

The evidence base requires appropriate clinical trials, with additional endpoints including clinical symptoms of patients and additional biochemical parameters beyond plasma B12 levels alone before these alternative routes can be recommended with confidence in clinical guidelines

doi:10.7326/M14-2841

You're managing two half-lives, two sets of side effects, two storage requirements, and potential interactions that no tox screen has evaluated

doi: 10.1007/BF02267720 345 KaurJKrishnanACSenadorDAlvarezAHannaHWOLearyDS