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Previous research revealed that NADPH oxidase 4 (NOX4), a source of cellular superoxide anions, induces FAO through carnitine palmitoyltransferase 1A (CPT1A) during NLR family pyrin domain-containing 3 (NLRP3) inflammasome activation and helps in the development of the inflammatory macrophage phenotype (76)

doi: 10.1038/s41598-023-40011-0 46 AlemannoFHoudayerEParmaASpinaADel FornoAScatoliniAet al

Epilepsia 49, 812

Beyond central adaptations, endurance training promotes peripheral remodeling, including increased mitochondrial content and capillary density in skeletal muscle, thereby improving oxygen extraction and utilization during exercise (61)

Later, Hornig and colleagues also suggested disturbed IL-1 signaling and autoimmunity-type patterns of immune activation while analyzing the cerebrospinal fluid in patients with atypical clinical characteristics (Hornig et al