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Cyclosporin-induced liver injury is caused by complex mechanisms that include oxidative stress, inflammation, apoptosis, and disruption of cellular metabolism

106 MaybinJ

Glutathione S-transferase pi localizes in mitochondria and protects against oxidative stress

Mechanisms of NO dysregulation NO deficiency can occur through mechanisms such as eNOS uncoupling, abnormal phosphorylation, inhibition by endogenous methylarginines, and increased NO degradation due to ROS