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doi: 10.1556/avet.2013.021 110 SongJ.YuJ.PrayogoG

However, a recent study showed that activating HIF1, but not HIF2, regulates the hepatic kynurenine pathway and contributes to neuromotor deficits under both physiological conditions and high-Mn conditions 142 , suggesting that HIF1 and HIF2 control Mn overload-mediated neurotoxicity via distinct mechanisms