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doi:10.1016/j.rmed.2016.06.015 20 Skvarc, D

As a result, pro-inflammatory cytokines, including interleukins and TNF- (tumor necrosis factor ), are transcribed [132]

SOD1 maturation involves the dimerisation of two apoSOD1 monomers to form a holoSOD1 dimer, which is dependent upon key posttranslational modifications to the immature apo metalloform: the binding of one Zn and Cu ion per monomer, intramonomeric disulfide bridging and homodimerisation