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As an important ketone body, -hydroxybutyrate has antioxidant and anti-inflammatory effects, reducing oxidative stress and protecting neurons by activating the Nrf2 signaling pathway (19, 55)

Selenium is a key cofactor for the enzymes iodothyronine deiodinases and thyroid peroxidase (TPO)

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Visual behavioral assessments are often ignored in preclinical studies but are important to evaluate any overall improvement in functional vision after neurotherapeutics to the the eye and the brains visual system

When glucose becomes limiting, cells can increase glutamine utilization or activate alternative carbon sources