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Interpretive criteria and measurement of methylmalonic acid in urine The reduced specificity of plasma MMA during renal impairment has led to the development of the uMMA/C ratio in the diagnosis of B12 deficiency

Individuals with specific single nucleotide polymorphisms (SNPs) impacting B12 absorption may benefit more from certain forms of Vitamin B12. However, since these SNPs are not typically included in commercial tests, individuals may need to experiment with different B12 forms sequentially or opt for a supplement containing a combination of all three naturally occurring forms of B12 for potentially faster clinical improvements

Also, it aids in maintaining the nerve cells and is a component in DNA construction