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That is why oral trials use gram-scale totals (1.8-2 g/day is typical) to land a meaningful amount in circulation

Studies have demonstrated that when iron accumulates in the body, it may be accompanied by OS, inflammation and CD (Masaldan et al., 2019)

A respiratory AE was defined as serious if it resulted in any of the following outcomes: death, life-threatening conditions, initial or prolonged hospitalization, disability or permanent damage, congenital anomalies, or other clinically significant medical events ( Figure 1