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Besides functioning as a NO donor, GSNO can also mediate protein S -glutathionylation (Chiueh and Rauhala, 1999)

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Synthetic small molecule SIRT1 activators Compared with natural products, synthetic SIRT1 activators offer several advantages, including defined molecular structures, high target selectivity, and stable pharmacokinetic profiles, making them a promising direction for the clinical application of SIRT1-targeted therapies

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