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Dosage and Protocol Duration: Dosage in preclinical studies is often calculated based on body weight, typically in micrograms (mcg) per kilogram (kg)

Risk of peripheral neuropathy with prolonged high-dose B6 Pain reduction: Within 3-5 doses Improved sensation: 2-4 weeks Nerve conduction: 6-8 weeks for measurable changes Maximum benefit: After 3 months of regular therapy Effects are cumulative and dose-dependent